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The researchers notably found that epithalamin not only produces direct antioxidant effects, but also stimulates the expression of antioxidant enzymes like superoxide dismutase and ceruloplasmin [10]

A recent clinical trial evaluated empagliflozin as an add-on to citalopram in 90 patients with moderate to severe depression, showing significant reductions in the Hamilton Depression Rating Scale and depressive symptoms at weeks 4 and 8 [193]

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The researchers observed increases in several markers commonly associated with early nerve-cell development and proposed that Epithalon may act partly through epigenetic interactions with chromatin-associated proteins